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In a scopolamine-induced cognitive impairment model in rats, Dihexa administered intracerebroventricularly (0.1 to 1.0 nmol), intraperitoneally (up to 0.5 mg/kg/day), or orally (up to 2.0 mg/kg/day) significantly improved performance on the Morris water maze (reduced latency to locate the hidden platform and increased time spent in the target quadrant during probe trials) compared with scopolamine-treated, Dihexa-untreated animals, with the highest doses producing performance indistinguishable from non-impaired controls

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Approximately 91.9% of participants taking CagriSema achieved a body weight reduction greater than or equal to 5%, compared to 31.5% for participants in the placebo group

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